Moving Laser Diffraction from the Lab to the Production Process

September 27, 2012

2 Min Read
Moving Laser Diffraction from the Lab to the Production Process
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In a new presentation from Malvern Instruments entitled, “Moving laser diffraction from the laboratory into the production process”, product group manager Dr. Paul Kippax discusses the benefits and challenges of taking laboratory-based particle sizing out into the production process.     

The presentation is particularly tailored to the pharmaceutical industry but is generally relevant to all manufacturers considering an investment in on-plant real-time particle size measurement. It can be freely downloaded at:

Particle size information is used in the development and manufacture of a significant number of products, with laser diffraction now the analytical technique of choice across many industries. A key attraction of the method is the availability of process systems for real-time measurement that complement highly productive laboratory instruments. However, some still perceive the transition from lab to line as potentially problematic and consequently fail to fully exploit the potential of this powerful analytical method.

In the presentation, Dr. Kippax looks at how particle size information is used to understand and control product performance, and examines the application and benefits of both off- and on-line measurement. He reviews the primary requirements of a process analyzer, which are to deliver relevant information, in a relevant timeframe, using an appropriately robust device, and goes on to outline how laser diffraction process systems, as exemplified by Malvern’s Insitec range, meet these challenges, by combining rapid measurement with high reliability.

Installed in the process line or on an associated sampling loop, these systems deliver the real-time monitoring that underpins optimized, often automated, control, and can return substantial economic return. Throughout the presentation the focus is on how best to apply laser diffraction technology to meet requirements, whether in research, development, manufacture, or QC, and how to ensure the successful application of the technique across the product lifecycle.

To view the presentation or for other presentations, webinars, and support on the implementation of on-line particle sizing, visit

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